Study results offer safe and affordable treatment option.
A Canadian clinical trial led by researchers at the University of Calgary’s Hotchkiss Brain Institute (HBI), at the Cumming School of Medicine (CSM), with the University of Montreal Hospital (CHUM) as one of the investigative sites, shows that minocycline, a common acne medication, can slow the progress of relapsing-remitting multiple sclerosis (MS) in people who have recently experienced their first symptoms.
In addition to being an unexpected discovery – an acne drug benefitting a neurological disorder – the discovery is significant as it offers a safe and affordable treatment option for those with early onset MS. This discovery could impact thousands of newly diagnosed MS patients around the world.
The results of the Phase 3 clinical trial were published today in the New England Journal of Medicine. The trial included 142 participants between the ages of 18 and 60 across 12 Canadian sites including: Vancouver, Burnaby, Calgary, Edmonton, Winnipeg, Ottawa, Toronto, London, Montreal, Quebec City and Halifax.
MS is thought to be an autoimmune disease of the central nervous system (brain, spinal cord). The disease attacks myelin, the protective covering of the nerves, causing inflammation and often damaging the myelin. The drug works by reducing the inflammation.
In Canada, the cost of current therapies for relapsing-remitting MS typically falls in the range of $20,000 to $40,000 per year; the minocycline treatment would cost a fraction of that at about $600 per year. In the United States, MS treatment often costs about three times as much as in Canada. Researchers say the potential cost saving will be tremendous and will improve access to treatment for people with MS.
Researchers and doctors are excited about the discovery, as there are no oral therapies approved in Canada for use at this very early stage of the disease.
The drug itself has been around for 50 years, and it doesn’t need further Health Canada approval to be used as an off label prescription for MS.
“The clinical results are compelling,” says HBI member Dr. Luanne Metz, the study’s lead author, who is also a professor in the Department of Clinical Neurosciences at the CSM and an Alberta Health Services neurologist. “Based on these findings, neurologists will be able to prescribe minocycline for people experiencing their first symptoms of demyelination if an MRI suggests the cause will likely prove to be MS.”
“Patients will now have yet another treatment option, one that does not require injections, monitoring lab work, or special authorization by their insurance company provided they have adequate coverage to begin with. These processes can delay treatment initiation for three to four months whereas minocycline can be started immediately,” says Dr. Pierre Duquette, neurologist and researcher at the University of Montreal Hospital Research Center (CRCHUM) and professor at the University of Montreal.
Current care for many individuals experiencing a first clinical attack suggestive of relapsing-remitting MS involves a brain MRI at about six months to determine if MS can be confirmed or treatment with injectable medications to reduce the chance that their condition will evolve to confirm MS.
“We have not cured MS, but this trial makes future treatment easy and affordable. It has global impact because there are countries where people with MS cannot be treated because of the very high cost,” says V. Wee Yong, PhD, a study author from the HBI and professor in the Department of Clinical Neurosciences.
Jill, 34, experienced her first sign that she could be developing MS at 27. She woke up with tingling in her hand, the numbness spread to 50 per cent of her body before she received confirmation that lesions had formed on her brain and spine. She volunteered for the two-year clinical trial and kept taking the drug after the trial ended. She is now symptom free and not been diagnosed with MS. After being on the drug for six years, Jill consulted with her physician and decided to stop taking the medication. “It is an antibiotic, and I wanted to give my body a break from all medication. I may go back on minocycline at some point. It’s great to have this option.”
Participants in the trial who were experiencing their first demyelinating symptoms were randomized to receive 100 mg twice daily of the oral minocycline or placebo. Over six months of treatment, there was a 27.6 per cent reduction of becoming full blown MS. (The risk was 61 per cent in the placebo group and 33.4 percent in the minocycline group.) This is similar to the effects of current therapies.
“This study highlights the benefits of evaluating existing therapies for other indications. Minocycline is an existing acne medication which is safe, and well-tolerated and it is available for immediate clinical use,” says Dr. Pierre Duquette.
The early stages of this work were supported by the Canadian Institutes of Health Research (CIHR) and community support. The clinical trial was supported by Multiple Sclerosis Society of Canada and the Multiple Sclerosis Scientific Research Foundation (MSSRF).
Source : Research Institute of MUHC